The 2nd Air Maintenance Factory Directorate (AFMD) was established as Turkey's first aircraft factory (Kayseri Aircraft Factory) by "Turkish Aircraft & Motor Incorporated Company (TOMTAŞ)," which was formed jointly by the Turkish Aeroplane League and the German company Junkers Aircraft & Motor Works under the agreement signed on August 15, 1925, and the factory was officially inaugurated with a ceremony held on October 6, 1926. However, due to the disagreement between the company and the government over financing issues, the company had to go bankrupt on May 3, 1928, and the factory was closed. In 1930, the company was liquidated, and the facility was transferred to the Ministry of National Defense. After 1933, multiple agreements were signed with the USA, Germany, Poland, and England, and with the outstanding efforts of Turkish engineers and workers, the production of Curtiss Hawk, Curtiss Fledgling, Gotha Go 145, Peletel PZL 24A, and Miles Magister aircraft was started under license. Since 1950, the name of the facility was changed to the "Air Supply Maintenance and Maintenance Center," and in 1970, it was included in the "Reorganization and Modernization (REMO)" Project and became an "Air Supply and Maintenance Center." On July 1, 1975, its name was changed to the 'Supply and Maintenance Center Command,' and on February 19, 1986, the name of the facility was changed to the '2nd Air Supply and Maintenance Center Command'. 

In 2016, the General Directorate of Military Factories was established under the Ministry of National Defense to ensure the effective management of the Military Factories of the Turkish Armed Forces (TAF) under a single financial and administrative authority. The 2nd Air Supply and Maintenance Center, one of the 3 Air Supply Maintenance Centers that were previously part of the Turkish Air Force, started to operate as the 2nd Air Maintenance Factory Directorate under the General Directorate of Military Factories after an organizational change in 2017.